Year: 1986
Type: article
Abstract: Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized.
Institutions: Harvard University, United States Navy, Walter Reed Army Institute of Research, Naval Medical Research Command, National Cancer Institute, National Cancer Institute, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Wilkes University
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2010346569