Year: 2013
Type: article
Study design: Observational Study
Abstract: To date, there has been little work describing the neurochemical profile of young, heavy marijuana users. In this study, we examined 27 young-adult marijuana users and 26 healthy controls using single-voxel magnetic resonance spectroscopy on a 3 T scanner. The voxel was placed in the dorsal striatum, and estimated concentrations of glutamate + glutamine, myo-inositol, taurine + glucose, total choline and total N-acetylaspartate were examined between groups. There were no overall group effects, but two metabolites showed group by sex interactions. Lower levels of glutamate + glutamine (scaled to total creatine) were observed in female, but not male, marijuana users compared to controls. Higher levels of myo-inositol were observed in female users compared to female non-users and to males in both groups. Findings are discussed in relation to patterns of corticostriatal connectivity and function, in the context of marijuana abuse.
Source: NeuroImage Clinical
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,490
Funders: University of Minnesota, National Institutes of Health, Center for Neurobehavioral Development, Minnesota Supercomputing Institute, University of Minnesota, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources
Awards: G1333106770, G1412490956, G1698840832, G1861255037, G190114646, G2340896798, G2617303313, G3358121054, G3534199216, G3969884740, G4294528575, NMR Imaging and Spectroscopy, G618986598, G643968534, Institutional Center Cores for Advanced Neuroimaging, Adolescent Brain Development and Effects of Drug Abuse
OpenAlex ID: W2010351733