The Effects of Adrenocorticotropic Hormone and Cortisone in the Adrenogenital Syndrome Associated With Congenital Adrenal Hyperplasia: an Attempt to Explain and Correct Its Disordered Hormonal Pattern 12
Year: 1951
Type: article
Abstract: The adrenogenital syndrome associated with congenital adrenal hyperplasia (1) is in many of its aspects the direct opposite of the other syndrome which may result from adrenal hyper-plasia, namely, Cushing's syndrome (2). For example, the former is characterized by rapid growth before epiphyseal closure, and an increase in strength, muscle mass, and skin thickness, whereas the latter is characterized by cessation of growth before epiphyseal closure, and a decrease in strength, muscle mass and skin thickness. Since the effect of adrenocorticotropic hor-mone (ACTH) in subjects with normal adrenals is essentially to produce a temporary "Cushing's syndrome medicamentosa " (3-7) it was of interest to observe the effects of ACTH in the adreno-genital syndrome. The first part of this report concerns the effects of ACTH in three female pa-tients with the adrenogenital syndrome. The results, which were surprising, led to the supposition that cortisone might inhibit the exces-sive production of androgens in these patients. The second part of this report concerns the ef-fects of cortisone in two female patients with the adrenogenital syndrome. METHOD With the exception of the long-term studies which are still in progress (vide infra) all studies were carried out
DOI: 10.1172/jci102438
Institutions: Harvard University, Massachusetts General Hospital
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2010358629