Work

A fragment based click chemistry approach towards hybrid G-quadruplex ligands: design, synthesis and biophysical evaluation

Year: 2011

Type: article

Abstract: A library of hybrid oxazole–triazole based compounds containing contiguously linked aromatic units were synthesised as G-quadruplex binding ligands. The design of these ligands was based upon combining features of our first generation of G-quadruplex bis-triazole ligands and the natural product telomestatin. The syntheses and biophysical studies of these ligands are described.

Source: Tetrahedron

DOI: 10.1016/j.tet.2011.10.066

Authors: Dougal J. Ritson, John E. Moses

Institution: University of Nottingham

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,680

Funders: University of Nottingham, Engineering and Physical Sciences Research Council