Work

Survivin the battle against immunosuppression

Year: 2012

Type: article

Abstract: Improving on the limited success of cancer immunotherapy requires new approaches to inhibit immunosuppressive pathways initiated by tumor cells to "escape" protective immunity. One unique approach utilizes Salmonella for systemic delivery of inhibitory RNA, targeting the immunosuppressive molecule Stat3, and a Survivin vaccine to suppress growth of aggressive murine tumors.

Source: OncoImmunology

DOI: 10.4161/onci.1.2.18180

Authors: Edwin R. Manuel, Céline A. Blache, Joshua D.I. Ellenhorn, Don J. Diamond

Institutions: City Of Hope National Medical Center, City of Hope

Language: English

Topic: Cancer Research and Treatments

Subfield: Biotechnology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913