Work

Direct Growth of Vertically-oriented Graphene for Field-Effect Transistor Biosensor

Year: 2013

Type: article

Abstract: A sensitive and selective field-effect transistor (FET) biosensor is demonstrated using vertically-oriented graphene (VG) sheets labeled with gold nanoparticle (NP)-antibody conjugates. VG sheets are directly grown on the sensor electrode using a plasma-enhanced chemical vapor deposition (PECVD) method and function as the sensing channel. The protein detection is accomplished through measuring changes in the electrical signal from the FET sensor upon the antibody-antigen binding. The novel biosensor with unique graphene morphology shows high sensitivity (down to ~2 ng/ml or 13 pM) and selectivity towards specific proteins. The PECVD growth of VG presents a one-step and reliable approach to prepare graphene-based electronic biosensors.

Source: Scientific Reports

DOI: 10.1038/srep01696

Authors: Shun Mao, Kehan Yu, Jingbo Chang, Douglas A. Steeber, Leonidas E. Ocola, Junhong Chen

Institutions: University of Wisconsin–Milwaukee, Argonne National Laboratory, Center for Nanoscale Materials

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,690

Funders: National Science Foundation, U.S. Department of Energy, University of Wisconsin-Milwaukee, Argonne National Laboratory