Work

Apoptotic donor leukocytes inhibit tolerance and limit mixed chimerism induced by CD40-CD154 blockade in allogeneic bone marrow transplantation

Year: 2006

Type: article

Abstract: Background: “Mini” transplants using non-myeloablative conditioning can avoid early post-transplant toxicity associated with myeloablative conditioning prior to allogeneic hematopoietic progenitor cell transplantation (HPCT), but graft-versus-host-disease (GvHD) and graft rejection remain clinical problems. We previously found that low-dose busulfan conditioning and costimulatory blockade using anti-CD154 monoclonal antibody (mAb) were sufficient to establish stable mixed chimerism without GvHD when transplanting moderate doses of T cell depleted bone marrow (TCD-BM) from MHC fully mismatched donors (Adams et al, J Immunol 167:1103, 2001).

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.250

Authors: J.-M. Li, C.R. Giver, J. Gorechlad, C.P. Larsen, E.K. Waller

Institutions: Emory University, Winship Cancer Institute

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650