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Antitumor efficacy of D2C7-(scdsFv)-PE38KDEL, a novel immunotoxin targeting EGFRwt and EGFRvIII, by convection-enhanced delivery in orthotopic brain tumor mouse models

Year: 2013
Type: article
Abstract: Meeting abstracts The epidermal growth factor receptor (EGFR) gene is most frequently amplified and overexpressed, along with its truncated mutant, EGFRvIII, in glioblastomas. We tested the antitumor efficacy of the recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL (D2C7-IT), which is reactive with a
DOI: 10.1186/2051-1426-1-s1-p126
Authors: Xuhui Bao, Vidyalakshmi Chandramohan, Stephen T Keir, Charles N Pegram, Roger E McLendon, Chien-Tsun Kuan, Ira H Pastan, Darell D Bigner
Language: English
Subfield: Immunology
Open Access status: gold
Estimated APC paid: $2,490
OpenAlex ID: W2010598098
FWCI: 0.291
Cites:
Cited by: 3
Related to: 10