Work

Sex steroids, bone mass, and bone loss. A prospective study of pre-, peri-, and postmenopausal women.

Year: 1996

Type: article

Abstract: Although bone loss around the time of menopause is driven by estrogen deficiency, the roles of estrogens and androgens in the preservation of skeletal mass at other stages of life are less well understood. To address this issue we studied 231 women between the ages of 32 and 77 with multiple measurements of sex steroids and bone mass over a period of 2-8 yr. In all women bone mass was negatively associated with concentrations of sex-hormone binding globulin, and positively associated with weight. Bone loss occurred from all skeletal sites in peri- and postmenopausal women, but premenopausal women lost bone only from the hip (-0.3%/yr) and had positive rates of change in the radius and spine. Bone loss was significantly associated with lower androgen concentrations in premenopausal women, and with lower estrogens and androgens in peri- and postmenopausal women. Sex steroids are important for the maintenance of skeletal integrity before menopause, and for as long as 20-25 yr afterwards.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci118382

Authors: C Slemenda, C Longcope, M Peacock, S Hui, C C Johnston

Institutions: Indiana University Indianapolis, Indiana University School of Medicine, University of Massachusetts Chan Medical School, Riley Hospital for Children, Indiana University – Purdue University Indianapolis

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2010868848

FWCI: 25.43

Cites: 19

Cited by: 303

Related to: 9