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Two cases of toxic anterior segment syndrome from generic trypan blue

Year: 2010

Type: article

Abstract: We report 2 cases of toxic anterior segment syndrome (TASS) resulting from impurities in generic trypan blue that was administered intracamerally to improve visualization of the capsule. Histology of the corneal buttons revealed foci of inflammatory response and complete loss of endothelial cells. Cell culture analysis showed that the generic trypan blue was approximately twice as toxic to the endothelium as a proprietary trypan blue. Ophthalmologists should be aware that any substance administered intraocularly can be a source of complications, and they should know the source of all material used in surgery.

Source: Journal of Cataract & Refractive Surgery

DOI: 10.1016/j.jcrs.2010.09.017

Authors: Kurt Buzard, Jue-Rong Zhang, Gabriella Thumann, Renata Stripecke, Murad Sunalp

Institutions: University of Nevada, Las Vegas, University of Cologne, Medizinische Hochschule Hannover, University of California, Berkeley

Language: English

Topic: Intraocular Surgery and Lenses

Subfield: Ophthalmology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2011310180

FWCI: 4.391

Cites: 25

Cited by: 52

Related to: 10