Longitudinal Antiretroviral Adherence in HIV+ Ugandan Parents and Their Children Initiating HAART in the MTCT-Plus Family Treatment Model: Role of Depression in Declining Adherence Over Time
Year: 2009
Type: article
Study design: Observational Study
Abstract: We conducted a study to assess the effect of family-based treatment on adherence amongst HIV-infected parents and their HIV-infected children attending the Mother-To-Child-Transmission Plus program in Kampala, Uganda. Adherence was assessed using home-based pill counts and self-report. Mean adherence was over 94%. Depression was associated with incomplete adherence on multivariable analysis. Adherence declined over time. Qualitative interviews revealed lack of transportation money, stigma, clinical response to therapy, drug packaging, and cost of therapy may impact adherence. Our results indicate that providing ART to all eligible HIV-infected members in a household is associated with excellent adherence in both parents and children. Adherence to ART among new parents declines over time, even when patients receive treatment at no cost. Depression should be addressed as a potential barrier to adherence. Further study is necessary to assess the long-term impact of this family treatment model on adherence to ART in resource-limited settings.
Source: AIDS and Behavior
Institutions: University of California, Berkeley, Cornell University, Infectious Diseases Institute, San Francisco General Hospital, University of California, San Francisco, University of California System, Mbarara University of Science and Technology, MUJHU Research Collaboration, Makerere University, Harvard University, Massachusetts General Hospital
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,590
Awards: HIV Outcomes Research and Training in Uganda, UCB/UCSF AIDS International Training and Research Program (AITRP), G3494962416, Novel approaches to monitoring and utilizing adherence to HIV therapy in Africa, Measurement of Alcohol Use Among HIV-Positives in Uganda, Mentoring Patient Oriented Adherence Research in Uganda
OpenAlex ID: W2011311582