Nonreplication of an association of SGIP1 SNPs with alcohol dependence and resting theta EEG power
Year: 2011
Type: article
Study design: Observational Study
Abstract: A recent study in a sample of Plains Indians showed association between eight single nucleotide polymorphisms (SNPs) located in the SGIP1 gene and resting θ electroencephalogram (EEG) power. This association appeared to generalize to alcohol use disorders, for which EEG power is a potential endophenotype. We analyzed a large, diverse sample for replication of the association of these implicated SGIP1 SNPs (genotyped on the Illumina 1M platform) with alcohol dependence (N=3988) and θ EEG power (N=1066). We found no evidence of association of the earlier implicated SGIP1 SNPs with either alcohol dependence or θ EEG power (all P>0.15) in this sample. The earlier implicated SNPs located in SGIP1 gene showed no association with alcohol dependence or θ EEG power in this sample of individuals with European and/or African ancestry. This failure to replicate may be the result of differences in ancestry between this sample and the original sample.
Source: Psychiatric Genetics
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Awards: G1083756078, G1270179341, Study of Addiction: Genetics and Environment, G3521947114, G363841575, G3799582765, G4280679160, Genome Wide Association Coordinating Center, G4862916304, G5149761344, G5831677909, G5885674059, JH/CIDR Genotyping for Genome-Wide Association Studies, FAMILY STUDY OF COCAINE DEPENDENCE, G746875028, G8161118679, G8267674335, G858805679, Genotyping for Studying the Genetic Contributions to Human Disease, G8869861501, G8924909668
OpenAlex ID: W2011413472