Work

Matricryptins and matrikines: biologically active fragments of the extracellular matrix

Year: 2014

Type: review

Abstract: Numerous extracellular proteins and glycosaminoglycans (GAGs) undergo limited enzymatic cleavage resulting in the release of fragments exerting biological activities, which are usually different from those of the full-length molecules. In this review, we define matrikines and matricryptins, which are bioactive fragments released from the extracellular matrix proteins, proteoglycans and GAGs and report their major biological activities. These fragments regulate a number of physiopathological processes including angiogenesis, cancer, fibrosis, inflammation, neurodegenerative diseases and wound healing. The challenges to translate these fragments from molecules biologically active in vitro and in experimental models to potential drugs are discussed in the last part of the review.

Source: Experimental Dermatology

DOI: 10.1111/exd.12435

Authors: Sylvie Ricard‐Blum, Romain Salza

Institutions: Lyon 1 Université, Centre National de la Recherche Scientifique, Institut de Biologie et de Chimie des Protéines, Microbiologie moléculaire et biochimie structurale

Language: English

Topic: Proteoglycans and glycosaminoglycans research

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2011478609

FWCI: 1.771

Cites: 161

Cited by: 224

Related to: 10