Human Papillomavirus Prevalence in Invasive Anal Cancers in the United States Before Vaccine Introduction
Year: 2013
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: This study aimed to conduct a representative survey of human papillomavirus (HPV) prevalence and its genotype distribution in invasive anal cancer specimens in the United States. MATERIALS AND METHODS: Population-based archival anal cancer specimens were identified from Florida, Kentucky, Louisiana, and Michigan cancer registries and Surveillance, Epidemiology, and End Results (SEER) tissue repositories in Hawaii, Iowa, and Los Angeles. Sections from 1 representative block per case were used for DNA extraction. All extracts were assayed first by linear array and retested with INNO-LiPA if inadequate or HPV negative. RESULTS: Among 146 unique invasive anal cancer cases, 93 (63.7%) were from women, and 53 (36.3%) were from men. Human papillomavirus (any type) was detected in 133 cases (91.1%) and 129 (88.4%) contained at least 1 high risk-type, most (80.1%) as a single genotype. Human papillomavirus type 16 had the highest prevalence (113 cases, 77.4%); HPV types 6, 11, 18, and 33 were also found multiple times. Among HPV-16-positive cases, 37% were identified as prototype variant Ep, and 63% were nonprototypes: 33% Em, 12% E-G131G, 5% Af1, 4% AA/NA-1, 3% E-C109G, 3% E-G131T, 2% As, and 1% Af2. No significant differences in the distributions of HPV (any), high-risk types, or HPV-16/18 were seen between sex, race, or age group. CONCLUSIONS: The establishment of prevaccine HPV prevalence in the United States is critical to the surveillance of vaccine efficacy. Almost 80% of anal cancers were positive for the vaccine types HPV-16 or HPV-18, and in 70%, these were the only types detected, suggesting that a high proportion might be preventable by current vaccines.
Institutions: University of Hawaiʻi at Mānoa, University of Iowa, Cedars-Sinai Medical Center, Centers for Disease Control and Prevention, University of Hawaii System, University of Kentucky, University of Florida, University of Hawaii Cancer Center, Michigan Department of Health and Human Services, Florida Department of Health, Louisiana State University, Louisiana State University Health Sciences Center New Orleans, Battelle
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Surveillance, Epidemiology and End Results (SEER) Program - Iowa, G1380205759, G1891143572, G1932976417, G1938264392, #14: Residual Tissue Repository to Create HIV Cancer Tumor Tissue Microrarrays , G2925750098, G3205575695, G3651850380, WS No. 12 Patterns of Care DX Year 2008, G3979874745, G4146105916, G4653999356, G4727689106, G6257715110, G667355291, G6989169551, G702041046, G7278087418, G918865625
OpenAlex ID: W2011502878