Work

Redirecting the Immune Response: Role of Adoptive T Cell Therapy

Year: 2010

Type: review

Abstract: Adoptive T cell therapy is aimed at overcoming constraints of the endogenous immune response. In patients with malignancies, this approach is based on the possibility of administering sufficient numbers of tumor-reactive lymphocytes under conditions in which they will promote a therapeutic response. Although this strategy is potentially applicable to a vast number of malignancies, its efficacy, to date, has been limited. This is likely related to several factors including an insufficient persistence and reactivation of infused cells, insufficient tumor infiltration, and the presence of an immunosuppressive environment. Here, we review the importance of pretransplantation host conditioning and posttransplantation strategies that have been shown to contribute to the therapeutic efficacy of infused T lymphocytes.

Source: Human Gene Therapy

DOI: 10.1089/hum.2010.033

Authors: Anna Mondino, Valérie Dardalhon, Rodrigo Hess Michelini, Severine Loisel-Meyer, Naomi Taylor

Institutions: Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Centre National de la Recherche Scientifique, Institut de Génétique Moléculaire de Montpellier

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Agence Nationale de la Recherche, Institut National de la Santé et de la Recherche Médicale, National Institute of Allergy and Infectious Diseases