Work

Inhibition of the aspartic proteinase from HIV‐2

Year: 1989

Type: article

Abstract: Kinetic constants were determined for the interaction of the HIV-2 aspartic proteinase with a synthetic substrate and a number of inhibitors at several pH values. Acetyl-pepstatin was more effective towards HIV-2 proteinase than the renin inhibitor, H-261; this effect is exactly the opposite from that observed previously for the proteinase from the HIV-1 AIDS virus.

Source: FEBS Letters

DOI: 10.1016/0014-5793(89)80961-5

Authors: Anthony D. Richards, Anne V. Broadhurst, Alison J. Ritchie, Ben M. Dunn, John Kay

Institutions: University of Wales, Roche (United Kingdom), University of Florida

Language: English

Topic: Protease and Inhibitor Mechanisms

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Medical Research Council