Work

The availability of bound nicotinic acid to the rat

Year: 1959
Type: article
Abstract: I n an earlier paper (Kodicek, Braude, Kon & Mitchell, 1959) the reviewed evidence showed that maize and other cereals contain almost all their nicotinic acid in a bound form which is unlike any of the known nicotinoyl compounds in being unavailable to rats, dogs, poultry or pigs and, probably, man.For the rat or pig the full biological activity of bound nicotinic acid in maize and other cereals can be released by hydrolysis with 0.5 N-NaOH, which liberates free nicotinic acid (Chaudhuri & Kodicek, 1950;Kodicek, 1951;Harper, Punekar & Elvehjem, 1958;Kodicek et. al. 1956).Maize cooked with lime-water, as in the preparation of tortilla in Central America and particularly in Mexico, has been reported to cure nicotinic-acid deficiency in rats (Laguna & Carpenter, 1951 ;
Authors: E. Kodicek, P. W. Wilson
Language: English
Subfield: Rheumatology
Field: Medicine
Open Access status: bronze
OpenAlex ID: W2011927238
FWCI: 3.71
Cites: 42
Cited by: 30
Related to: 10