Year: 1977
Type: article
Study design: Case Report
Abstract: Adriamycin infiltration into subcutaneous tissues during intravenous administration results in an intense inflammatory response, which may progress to full-thickness skin ioss and irreversible damage to underlying tendons and neurovascular structures. An analysis of 10 patients seen with Adriamycin in filtration indicated that healing of ulcerated lesions is often prolnged and associated with significant morbidity. Seven patients suffered skin ulcerations and three had severe functional impairment due to joint contractures. Adriamycin should not be infused near joints if possible . Surgical excision of ulcers is advocated if healing is prolonged. Proper local therapy, as well as early attention to proper splinting and physical therapy, can help reduce ultimate functional disability.
Source: Cancer
Institutions: National Institutes of Health, National Cancer Institute
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2011941911