Work

Agonistic 4-1bb antibodies in combination with inhibitory antibodies against CTLA-4, PD-L1 or LAG-3 ACT on CD8+ T cells in the tumor microenvironment and synergize to promote regression of established tumors

Year: 2014

Type: article

Abstract: Meeting abstracts Tumors can be placed into two categories: those that are T cell-inflamed and those that are not, based on specific chemokine and type I interferon gene expression signatures and CD8+ tumor infiltrating T cells (TIL). That these immune-inflamed tumors are not destroyed by the CD8+

Source: Journal for ImmunoTherapy of Cancer

DOI: 10.1186/2051-1426-2-s3-p213

Authors: Brendan Horton, Stefani Spranger, Jason Williams, Thomas Gajewski

Institution: University of Chicago

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,490