Year: 2003
Type: article
Abstract: Molecular and cytogenetic studies performed in 305 adult acute lymphoblastic leukaemia (ALL) patients enrolled in the gimema (Gruppo Italiano Malattie EMatologiche dell'Adulto) multicentric protocols identified an E2A-PBX1 fusion and/or t(1;19) in 10 patients (3.3%). All had common ALL, were mostly CyIg+ and were CD34/CD13/CD33-. Nine patients achieved a complete remission (CR); five patients showed a haematological relapse after 7 months (median). Four patients are alive in first CR with a median follow-up of 29 months; three patients are molecularly negative. This abnormality is frequently associated with early treatment failure. E2A-PBX1+ adult ALL should be considered for intensified treatment strategies and monitoring of minimal residual disease.
Source: British Journal of Haematology
Authors: Robin Foa, Antonella Vitale, Marco Mancini, Antonio Cuneo, Cristina Mecucci, Loredana Elia, Romina Lombardo, Giuseppe Saglio, Giuseppe Torelli, Luciana Annino, Giorgina Specchia, Eugenio Damasio, Anna Recchia, Francesco Di Raimondo, Enrica Morra, Ettore Volpe, Agostino Tafuri, Paola Fazi, Stephen P. Hunger, Franco Mandelli
Institutions: Sapienza University of Rome, University of Ferrara, University of Perugia, Ospedale San Luigi Gonzaga, University of Modena and Reggio Emilia, University of Bari Aldo Moro, Ospedale Policlinico San Martino, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Azienda Ospedaliera S.Giuseppe Moscati
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2012188343