Year: 2012
Type: article
Study design: Observational Study
Abstract: HIV-infected individuals are at risk for decreased bone mineral density (BMD). The known risk factors for bone loss do not fully explain the increased risk in this population. There is emerging evidence that leptin, a hormone secreted by adipocytes, plays an important role in bone metabolism. Several studies have assessed the relationship between leptin and bone density in healthy adults, but there are few such studies in HIV-infected individuals. Furthermore, HIV infected individuals on antiretroviral therapy are at increased risk for altered fat distribution, which may impact the relationship between leptin and BMD. In a cross-sectional analysis of data in 107 HIV-infected men, we determined whether serum leptin levels were associated with whole-body BMD and bone mineral content measured by dual-energy X-ray absorptiometry (DEXA), after adjusting for confounders including body fat distribution. We found an inverse association between leptin and bone density in those with peripheral lipoatrophy, defined objectively as <3 kg appendicular fat by DEXA, but no such relationship was seen in those with >3 kg appendicular fat. This result suggests that fat distribution may modify the relationship between leptin and bone density.
Source: AIDS Research and Treatment
DOI: 10.1155/2012/103072
Authors: Madhu N. Rao, Morris Schambelan, Viva W. Tai, Donald I. Abrams, Hootan Khatami, Peter J. Havel, Giorgos Sakkas, Kathleen Mulligan
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,000
Funders: University of California, San Francisco General Hospital Foundation, National Institutes of Health, University of California, San Francisco, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Complementary and Integrative Health
Awards: G1061166693, G1135820963, G1643098866, Clinical and Translational Science Institute, G1716070624, G1733559171, G2188559229, Dietary Fructose: Hormones & TG/Lipoprotein Metabolism, G249498532, G2542408440, Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria, G2612718445, G3066912635, G316464960, Effects of sleep duration and architecture on insulin sensitivity, G3294161561, G3355258773, G3425715951, G366406518, G4157340353, G4305088852, G4350804880, Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resis, General Clinical Research Center, G4682994329, G4957154492, G5170122070, G5330735925, G5362493225, G5643687706, G5838402511, G5852313170, G6203669569, G652508755, G6683701334, G7092645225, G734567824, G758528517, G7663947864, G8012663987, G8249760227, G8633029381, G8898196887, G9000046666, G9000047291, G9000058261, G9000097277, G9000100981, G9000109905, G9000154741, G9000160578, G9000177322, G9000180334, G9000200584, G9000285476, G9000323803
OpenAlex ID: W2012242907