Year: 1976
Type: conference-abstract
Abstract: Putative transmitters and related substances were perfused through the guinea pig scala tympani while monitoring compound action potentials (AP) of the cochlear nerve and cochlear microphonics (CM). The following substances had no effect on the CM or AP when applied at 10 mM: GABA, glycine, L-alanine, β-alanine, histamine, norepinephrine, taurine, dopamine, and sodium acetate. Substances which had no effect on CM or AP at 1 mW but reduced the AP at 10 mW were glutamate, aspartate, citrate, 5-hydroxytryptamine, tyramine, and bicuculline methiodide. At 1 mM, the prostaglandins E1, E2, and F2α reduced the AP with no effect on the CM while F2β and A1 had no effect on the AP or CM. The mechanisms underlying the action of these substances is unknown. However, the results seem to eliminate some substances as afferent transmitters and suggest others. [Supported by NIH, USPHS Grant NS-11647-02.]
DOI: 10.1121/1.2003536
Author: R. P. Bobbin
Language: English
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2012271415