Work

Influence of positive end-expiratory pressure on cyclic recruitment and derecruitment during one breathing cycle in porcine acute lung injury

Year: 2014

Type: article

Abstract: Cyclic recruitment and derecruitment (R/D) of lung parenchyma during mechanical ventilation are responsible for atelectrauma. Theoretically, cyclic R/D can lead to varying degrees of pulmonary shunt fraction throughout the respiratory cycle. Measurements of dynamic pulmonary shunt fraction could help in assessing the degree of cylic R/D. However, common methods of measuring pulmonary shunt do not allow for dynamic serial measurements during one respiratory cycle. In this study, we measured serial dynamic pulmonary shunt fractions during one breathing cycle and investigated the effect of positive end-expiratory pressure (PEEP) on cyclic R/D in artificially ventilated pigs before and after saline washout induced acute lung injury.

Source: Critical Care

DOI: 10.1186/cc13470