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Ciprofloxacin penetration into extravascular spaces in a rabbit model

Year: 1984

Type: article

Abstract: Ciprofloxacin penetration into extravascular spaces was studied in a rabbit Visking chamber model. The drug was administered (7 mg/kg) intramuscularly every 4 h for eight doses. Peak and trough drug levels by dose 8 were 1.3 and 0.35 micrograms/ml in serum and 0.61 and 0.50 micrograms/ml in extravascular sites. The ratio of extravascular site to serum free drug area under the drug curve by dose 8 was 91.1%. This potent, new antimicrobial agent appears to distribute freely to extravascular spaces in this animal model.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.26.6.935

Authors: K L Nichol, L R Peterson, C E Fasching, D N Gerding

Language: English

Topic: Antibiotics Pharmacokinetics and Efficacy

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2012326959

FWCI: 1.291

Cites: 13

Cited by: 5

Related to: 10