Work

Vertebrate intestinal endoderm development

Year: 2011

Type: review

Abstract: The endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as associated organs. To generate a functional intestine, a series of highly orchestrated developmental processes must occur. In this review, we attempt to cover major events during intestinal development from gastrulation to birth, including endoderm formation, gut tube growth and patterning, intestinal morphogenesis, epithelial reorganization, villus emergence, as well as proliferation and cytodifferentiation. Our discussion includes morphological and anatomical changes during intestinal development as well as molecular mechanisms regulating these processes.

Source: Developmental Dynamics

DOI: 10.1002/dvdy.22540

Authors: Jason R. Spence, Ryan Lauf, Noah F. Shroyer

Institution: Cincinnati Children's Hospital Medical Center

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Developmental Paradigms to Direct Human Endoderm into Foregut Lineage, Training in Developmental and Perinatal Endocrinology, The role of ATOH1 as a tumor suppressor in colorectal cancer, SPDEF in intestinal differentiation., G7113003347