Work

Targeting LDL Cholesterol With LNA

Year: 2012

Type: article

Abstract: Cardiovascular disease is the number one cause of death in the industrialized world. Much of the morbidity and mortality from heart disease can be linked to elevated low-density lipoprotein (LDL) cholesterol, and one of the key genes that increases LDL cholesterol is Proprotein convertase subtilisin/kexin type 9 (PCSK9). In a recent study in nonhuman primates, Lindholm et al. demonstrate that a 1 month course of weekly subcutaneous therapy with either of two locked nucleic acid (LNA) antisense oligonucleotides targeting PCSK9 rapidly decreases the expression of both PCSK9 and circulating LDL cholesterol without reported toxicity.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1038/mtna.2011.8

Author: Arthur M Krieg

Institution: RaNA Therapeutics (United States)

Language: English

Topic: Lipoproteins and Cardiovascular Health

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900