Year: 2011
Type: review
Abstract: Mitochondrial processes play an important role in tumor initiation and progression.In this review, we focus on three critical processes by which mitochondrial function may contribute to cancer: through alterations in glucose metabolism, the production of reactive oxygen species (ROS) and compromise of intrinsic apoptotic function.Alterations in cancer glucose metabolism include the Warburg effect, leading to a shift in metabolism away from aerobic respiration toward glycolysis, even when sufficient oxygen is present to support respiration.Such alterations in cellular metabolism may favor tumor cell growth by increasing the availability of biosynthetic intermediates needed for cellular growth and proliferation.Mutations in specific metabolic enzymes, namely succinate dehydrogenase, fumarate hydratase and the isocitrate dehydrogenases, have been linked to human cancer.Mitochondrial ROS may contribute to cancer via DNA damage and the activation of aberrant signaling pathways.ROS鄄 dependent stabilization of the transcription factor hypoxia 鄄 inducible factor (HIF) may be a particularly important event for tumorigenesis.Compromised function of intrinsic apoptosis removes an important cellular safeguard against cancer and has been implicated in tumorigenesis, tumor metastasis, and chemoresistance.Each of the major mitochondrial processes is linked.In this review, we outline the connections between them and address ways these mitochondrial pathways may be targeted for cancer therapy.Key words Mitochondria, cancer, metabolism, apoptosis, reactive oxygen species Mitochondria are often described as the 野powerhouse冶 of the cell.While their role in ATP production is critical, mitochondria house numerous other biochemical reactions and lie at the intersection of multiple physiological processes including catabolic and anabolic metabolism, signaling, generation of reactive oxygen species (ROS) and apoptosis.Numerous studies indicate these mitochondrial processes may play an important role in tumor initiation and progression.In this review, we focus on three major processes by which mitochondrial function may contribute to cancer: through alterations in glucose metabolism, the production of ROS and through the compromise of apoptosis.
Source: 癌症：英文版
Institution: Van Andel Institute
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
Funder: National Cancer Institute
OpenAlex ID: W2012523643