Work

Lymphomas and leukemias in the relatives of patients with mycosis fungoides

Year: 1982

Type: article

Abstract: Of 526 consecutive patients with cutaneous T-cell lymphomas, 21 had first-degree relatives with lymphoproliferative or hematopoietic malignancies. Twenty-nine such tumors occurred in the 21 kindreds. Hodgkin's disease accounted for one-third of this total, with various leukemias (11 cases), non-Hodgkin's lymphoma (five cases), and multiple myeloma (three cases) comprising the remainder. These data suggest that genetically-determined immunoregulatory abnormalities may represent a shared pathway of oncogenesis in diverse lymphoproliferative and hematopoietic malignancies.

Source: Cancer

DOI: 10.1002/1097-0142(19820215)49:4<737::aid-cncr2820490423>3.0.co;2-r

Authors: Mark H. Greene, Harlan A. Pinto, Jeffrey A. Kant, Kathleen Siler, Eric C. Vonderheid, Stanford I. Lamberg, Nancy A. Dalager

Institutions: National Cancer Institute, National Institutes of Health, Temple University Health System, Temple University, Johns Hopkins University

Language: English

Topic: Cutaneous lymphoproliferative disorders research

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2012599110

FWCI: 2.524

Cites: 24

Cited by: 30

Related to: 10