Prolonged faecal excretion of poliovirus in a nurse with common variable hypogammaglobulinaemia
Year: 1991
Type: article
Study design: Case Report
Abstract: A nurse with common variable hypogammaglobulinaemia was found to excrete a non-vaccine strain type II poliovirus for almost a year following a bout of gastroenteritis. Attempts were made to halt intestinal carriage of the virus in view of the possible risk of spread to immunocompromised patients and the risk of paralytic poliomyelitis to the patient himself. Three doses of killed Salk vaccine failed to stimulate salivary anti-polio antibodies. Excretion of the virus ceased spontaneously just before oral immunoglobulin containing high titres of antibodies to polio virus was used to halt virus excretion.
Source: Postgraduate Medical Journal
Authors: S A Misbah, P A Lawrence, J B Kurtz, H M Chapel
Institutions: John Radcliffe Hospital, University of Oxford
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2012670542