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An Escherichia coli rpoB mutation that inhibits transcription of catabolite-sensitive operons

Year: 1991

Type: article

Abstract: The Escherichia coli rpoB636 mutant is defective in the transcription of lac and other catabolite-sensitive operons. The lac promoter variant, UV5, which is independent of cyclic AMP and the cyclic AMP receptor protein, CRP, was also defective in rpoB636 mutants. The activity of the lac UV5 promoter was restored to wild-type levels by deletion of cya (adenylate cyclase) or crp. Cyclic AMP and CRP apparently act as inhibitors of the rpoB636 RNA polymerase.

Source: Journal of Molecular Biology

DOI: 10.1016/0022-2836(91)90205-k

Authors: Patricia Rockwell, M.E. Gottesman

Institution: Columbia University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,730

OpenAlex ID: W2012750182

FWCI: 0.641

Cites: 39

Cited by: 7

Related to: 10