Work

Disease state prediction from resting state functional connectivity

Year: 2009

Type: article

Abstract: The application of multivoxel pattern analysis methods has attracted increasing attention, particularly for brain state prediction and real-time functional MRI applications. Support vector classification is the most popular of these techniques, owing to reports that it has better prediction accuracy and is less sensitive to noise. Support vector classification was applied to learn functional connectivity patterns that distinguish patients with depression from healthy volunteers. In addition, two feature selection algorithms were implemented (one filter method, one wrapper method) that incorporate reliability information into the feature selection process. These reliability feature selections methods were compared to two previously proposed feature selection methods. A support vector classifier was trained that reliably distinguishes healthy volunteers from clinically depressed patients. The reliability feature selection methods outperformed previously utilized methods. The proposed framework for applying support vector classification to functional connectivity data is applicable to other disease states beyond major depression.

Source: Magnetic Resonance in Medicine

DOI: 10.1002/mrm.22159

Authors: R. Cameron Craddock, Paul E. Holtzheimer, Xiaoping P. Hu, Helen S. Mayberg

Institutions: Georgia Institute of Technology, Emory University

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Emory University, National Institute of Mental Health, National Institute of Biomedical Imaging and Bioengineering, National Center for Advancing Translational Sciences