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Antimicrobial activity of synthetic magainin peptides and several analogues.

Year: 1988

Type: article

Abstract: We have previously reported the isolation of two broad-spectrum antimicrobial peptides ("magainins") from the skin of the African clawed frog Xenopus laevis. These natural peptides are active against many species of bacteria and fungi and also induce osmotic lysis of protozoa. In this report we demonstrate that synthetic magainin peptides appear to be indistinguishable from the natural products with respect to chromatographic properties and biological activity. These studies demonstrate conclusively that the magainin peptides are potent antimicrobial substances.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.85.3.910

Authors: M Zasloff, B Martin, H C Chen

Institution: National Institutes of Health

Language: English

Topic: Antimicrobial Peptides and Activities

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2013092938

FWCI: 10.07

Cites: 11

Cited by: 371

Related to: 10