Year: 1998
Type: article
Abstract: INTRODUCTION.To examine the molecular events associated with aging in mammals, we employed oligonucleotide-based arrays to define the transcriptional response to the aging process in mouse gastrocnemius muscle (1) and in two regions of the brain (cerebellum, neocortex) (2).We also studied the influence of retarded mammalian aging induced by caloric restriction (CR) (3, 4) on transcriptional patterns in these tissues.Our choice of tissues was guided by the fact that skeletal muscle and the brain are primarily composed of long-lived, high oxygen-consuming postmitotic cells, a feature shared with another critical aging target (the heart).
Source: Pathophysiology
Author: R. Weindruch
Institution: University of Wisconsin–Madison
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,689
OpenAlex ID: W2013257205