Work

Late-Stage Deoxyfluorination of Alcohols with PhenoFluor

Year: 2013

Type: article

Abstract: An operationally simple protocol for the selective deoxyfluorination of structurally complex alcohols is presented. Several fluorinated derivatives of natural products and pharmaceuticals have been prepared to showcase the potential of the method for late-stage diversification and its functional group compatibility. A series of simple guidelines for predicting the selectivity in substrates with multiple alcohols is given.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja3125405

Authors: Filippo Sladojevich, Sophie I. Arlow, Pingping Tang, Tobias Ritter

Institution: Harvard University

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Development of modern late-stage fluorination reactions with [18F]