Work

Dopamine Synthesis, Uptake, Metabolism, and Receptors: Relevance to Gene Therapy of Parkinson's Disease

Year: 1997

Type: review

Abstract: This article gives a brief overview of the current understanding of the life cycle of the dopamine molecule, covering dopamine synthesis, storage, release, receptor and autoreceptor interactions, and reuptake. Special consideration is given to biochemical changes that occur in the nigrostriatal dopamine system in Parkinson's disease and how gene therapy may provide a new strategy for reversing parkinsonian biochemical deficits.

Source: Experimental Neurology

DOI: 10.1006/exnr.1996.6379

Authors: John D. Elsworth, Robert H. Roth

Institution: Yale University

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,110