Work

The Promise of Integrins as Effective Targets for Anticancer Agents

Year: 2002

Type: article

Abstract: This review will briefly describe integrin function, address why integrins are attractive targets for chemotherapeutic drug design, and discuss some ongoing studies aimed at inhibiting integrin activity. Integrins are cell surface heterodimeric receptors. They modulate many cellular processes including: growth, death (apoptosis), adhesion, migration, and invasion by activating several signaling pathways. Many potential chemotherapeutic agents target integrins directly (eg, polypeptides, monoclonal antibodies, adenovirus vectors). These agents may be clinically useful in controlling the metastatic spread of cancer.

Source: BioMed Research International

DOI: 10.1155/s1110724302204015

Authors: William L. Rust, Stephen W. Carper, George E. Plopper

Institutions: Novartis (Switzerland), University of Nevada, Las Vegas, Rensselaer Polytechnic Institute

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680