Work

Regulation of p53 Stability and Apoptosis by a ROR Agonist

Year: 2012

Type: article

Abstract: Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0034921

Authors: Yongjun Wang, Laura A. Solt, Douglas J. Kojetin, Thomas P. Burris

Institutions: Scripps Research Institute, University of Illinois Chicago

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,382