Work

Microfluidic Confinement of Single Cells of Bacteria in Small Volumes Initiates High‐Density Behavior of Quorum Sensing and Growth and Reveals Its Variability

Year: 2009

Type: article

Abstract: One is a quorum: As few as one to three cells of Pseudomonas aeruginosa bacteria are confined in small volumes by the use of microfluidics. These small numbers of cells are able to activate quorum sensing (QS) pathways and achieve QS-dependent growth. The results also show that at low numbers of cells, initiation of QS is highly variable within a clonal population.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200901550

Authors: James Q. Boedicker, Meghan E. Vincent, Rustem F. Ismagilov

Institution: University of Chicago

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institutes of Health

Award: 2007 NIH Director's Pioneer Award Program (DP1)