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Cellular Thymidine Kinase Activity Is Required for the Inhibition of HIV-1 Replication by AZT in Lymphocytes

Year: 1994

Type: article

Abstract: In this report, we provide evidence that the cellular thymidine kinase activity is required for the inhibition of HIV replication by zidovudine (AZT) in lymphocytes. The HSV-1 thymidine kinase protein is not able to substitute for the cellular enzyme, in accord with in vitro data that AZT is poorly phosphorylated by the HSV-derived activity.

Source: Virology

DOI: 10.1006/viro.1994.1185

Authors: Israel Lowy, Manuel Caruso, Stephen P. Goff, David Klatzmann

Institutions: Centre National de la Recherche Scientifique, Pitié-Salpêtrière Hospital, Columbia University

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,160