Work

The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene

Year: 1985

Type: article

Abstract: We have isolated a unique fragment of the HLA-DR alpha gene and probed human genomic DNA at low stringency to search for homologous sequences. A minimum of six non-polymorphic cross-hybridizing high molecular weight fragments were found in all DNAs examined. In order to obtain molecular clones of these cross-hybridizing fragments, we constructed lambda and cosmid libraries of human DNA and screened them at low stringency with the HLA-DR alpha gene specific subclone. We have isolated clones corresponding to each of the six fragments and, in this paper, describe those which contain the gene encoding HLA-SB(DP) alpha.

Source: Nucleic Acids Research

DOI: 10.1093/nar/13.20.7515

Authors: Simon K. Lawrance, Hriday K. Das, Julian Pan, Sherman M. Weissman

Institution: Yale University

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institutes of Health

Award: MOLECULAR MAPPING OF IMMUNE RESPONSE &COMPLEMENT GENES