Work

Power in Voxel-based Lesion-Symptom Mapping

Year: 2007

Type: article

Abstract: Lesion analysis in brain-injured populations complements what can be learned from functional neuroimaging. Voxel-based approaches to mapping lesion-behavior correlations in brain-injured populations are increasingly popular, and have the potential to leverage image analysis methods drawn from functional magnetic resonance imaging. However, power is a major concern for these studies, and is likely to vary regionally due to the distribution of lesion locations. Here, we outline general considerations for voxel-based methods, characterize the use of a nonparametric permutation test adapted from functional neuroimaging, and present methods for regional power analysis in lesion studies.

Source: Journal of Cognitive Neuroscience

DOI: 10.1162/jocn.2007.19.7.1067

Authors: Daniel Y. Kimberg, H. Branch Coslett, Myrna F. Schwartz

Institutions: University of Pennsylvania, Moss Rehabilitation Hospital

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green