Work

Oxygen‐derived radicals from Trypanosoma cruzi‐stimulated human neutrophils

Year: 1983

Type: article

Abstract: This study provides biochemical and electron spin resonance spectroscopic evidence that contract of human polymorphonuclear leukocytes with antibody-coated Trypanosoma cruzi triggers the respiratory burst. Oxygen consumption, superoxide anion and hydrogen peroxide release were stimulated under conditions of polymorphonuclear leukocyte-mediated killing. This stimulation did not occur under non-killing conditions when antibody was omitted. A common mechanism of cytotoxicity of human polymorphonuclear leukocytes against different T. cruzi forms is suggested by the triggering of the respiratory burst by antibody-coated epimastigotes and trypomastigotes.

Source: FEBS Letters

DOI: 10.1016/0014-5793(83)80201-4

Authors: Roberto Docampo, Angela M. Casellas, Eliana D. Madeira, Rita L. Cardoni, Silvia N.J. Moreno, Ronald P. Mason