Year: 2011
Type: article
Abstract: The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.
Source: Development
DOI: 10.1242/dev.063834
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Funders: Howard Hughes Medical Institute, Stowers Institute for Medical Research, Agence Nationale de la Recherche, Max-Planck-Gesellschaft, National Institutes of Health, Advanced Research Projects Agency, Eunice Kennedy Shriver National Institute of Child Health and Human Development, FP7 Ideas: European Research Council
OpenAlex ID: W2014189420