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Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues

Year: 2004
Type: article
Abstract: Mammary gland development is a complex process that is dependent on interactions between the developing mammary epithelium and the surrounding stromal tissues. We show that mice lacking the triglyceride synthesis enzyme acyl CoA:diacylglycerol transferase 1 (DGAT1) have impaired mammary gland development, characterized by decreased epithelial proliferation and alveolar development, and reduced expression of markers of functional differentiation. Transplantation studies demonstrate that the impaired development results from a deficiency of DGAT1 in both the stromal and epithelial tissues. Our findings are the first to link defects in stromal lipid metabolism to impaired mammary gland development.
Source: Development
DOI: 10.1242/dev.01158
Authors: Sylvaine Cases, Ping Zhou, Jonathan M. Shillingford, Bryony S. Wiseman, Jo Dee Fish, Christina S. Angle, Lothar Hennighausen, Zena Werb, Robert V. Farese
Language: English
Subfield: Biochemistry
Open Access status: bronze
Funders: U.S. Department of Defense, Gladstone Institutes, National Institutes of Health, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences
Awards: G1347062185, G1442016638, G2520992140, G556115705, G557332211, Bay Area Breast Cancer & the Environment Research Center, G7802392664
OpenAlex ID: W2014290839
FWCI: 1.091
Cites: 49
Cited by: 56
Related to: 10