Work

Diffuse reflectance spectroscopy with a self-calibrating fiber optic probe

Year: 2008

Type: article

Abstract: Calibration of the diffuse reflectance spectrum for instrument response and time-dependent fluctuation as well as interdevice variations is complicated, time consuming, and potentially inaccurate. We describe a novel fiber optic probe with a real-time self-calibration capability that can be used for tissue optical spectroscopy. The probe was tested in a number of liquid phantoms over a relevant range of tissue optical properties. Absorption and scattering coefficients are extracted with an average absolute error and standard deviation of 6.9%+/-7.2% and 3.5%+/-1.5%, respectively.

Source: Optics Letters

DOI: 10.1364/ol.33.001783

Authors: Bing Yu, Henry Fu, Torre Bydlon, Janelle E. Bender, Nirmala Ramanujam

Institution: Duke University

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute

Award: Diagnosis of Breast Cancer with Optical Spectroscopy