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Sequence Changes Associated with Respiratory Transmission of H7N1 Influenza Virus in Mammals

Year: 2014

Type: editorial

Abstract: ing sequence changes in highly pathogenic avian influenza virus A H7N1 (A/H7N1) associated with airborne transmission in mam-mals (1). The authors found that serial inoculation of A/H7N1 into ferrets, housed under conditions allowing the transmission of virus by airborne routes but not by direct contact, led to the selec-tion of variants capable of ferret-to-ferret spread. Sequence changes in the viral polymerase PB2 subunit, nucleoprotein (NP), matrix protein (M1), and hemagglutinin (HA) were found in A/H7N1 variants following the tenth and final passage. Impor-tantly, these sequence changes were not associated with any loss in virulence. These findings raise the possibility that sequence poly-morphisms in influenza virus internal proteins, in addition to those previously described for HA (2–4), regulate airborne trans-mission of highly pathogenic avian influenza virus strains in mammals.

Source: Journal of Virology

DOI: 10.1128/jvi.00886-14

Authors: Terence S. Dermody, Rozanne M. Sandri-Goldin, Thomas Shenk

Institutions: Vanderbilt University, Vanderbilt University Medical Center, University of California, Irvine, Princeton University

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2014326355

Cites: 17

Cited by: 7

Related to: 10