Work

DNA replication components as regulators of epigenetic inheritance—lesson from fission yeast centromere

Year: 2014

Type: review

Abstract: Genetic information stored in DNA is accurately copied and transferred to subsequent generations through DNA replication. This process is accomplished through the concerted actions of highly conserved DNA replication components. Epigenetic information stored in the form of histone modifications and DNA methylation, constitutes a second layer of regulatory information important for many cellular processes, such as gene expression regulation, chromatin organization, and genome stability. During DNA replication, epigenetic information must also be faithfully transmitted to subsequent generations. How this monumental task is achieved remains poorly understood. In this review, we will discuss recent advances on the role of DNA replication components in the inheritance of epigenetic marks, with a particular focus on epigenetic regulation in fission yeast. Based on these findings, we propose that specific DNA replication components function as key regulators in the replication of epigenetic information across the genome.

Source: Protein & Cell

DOI: 10.1007/s13238-014-0049-9

Authors: Haijin He, Marlyn Gonzalez, Fan Zhang, Fei Li

Institutions: New York University, Tongji University, Shanghai Pulmonary Hospital

Language: English

Topic: Epigenetics and DNA Methylation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,700

Funder: National Science Foundation