Work

Lymphatic vessels in health and disease

Year: 2012

Type: article

Abstract: The lymphatic vasculature plays vital roles in tissue fluid balance, immune defense, metabolism, and cancer metastasis. In adults, lymphatic vessel formation and remodeling occur primarily during inflammation, development of the corpus luteum, wound healing, and tumor growth. Unlike the blood circulation, where unidirectional flow is sustained by the pumping actions of the heart, pumping actions intrinsic to the lymphatic vessels themselves are important drivers of lymphatic flow. This review summarizes critical components that control lymphatic physiology. WIREs Syst Biol Med 2013, 5:111–124. doi: 10.1002/wsbm.1201 This article is categorized under: Physiology > Mammalian Physiology in Health and Disease

Source: WIREs Systems Biology and Medicine

DOI: 10.1002/wsbm.1201

Authors: Cristina T. Kesler, Shan Liao, Lance L. Munn, Timothy P. Padera

Institutions: Harvard University, Massachusetts General Hospital

Language: English

Topic: Lymphatic System and Diseases

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases