Polymorphisms in DNA repair pathway genes, body mass index, and risk of non‐Hodgkin lymphoma
Year: 2013
Type: article
Study design: Observational Study
Abstract: We conducted a population-based case-control study in Connecticut women to test the hypothesis that genetic variations in DNA repair pathway genes may modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL). Compared to those with BMI <25, women with BMI ≥25 had significantly increased risk of NHL among women who carried BRCA1 (rs799917) CT/TT, ERCC2 (rs13181) AA, XRCC1 (rs1799782) CC, and WRN (rs1801195) GG genotypes, but no increase in NHL risk among women who carried BRCA1 CC, ERCC2 AC/CC, XRCC1 CT/TT, and WRN GT/TT genotypes. A significant interaction with BMI was only observed for WRN (rs1801195; P = 0.004) for T-cell lymphoma and ERCC2 (rs13181; P = 0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk.
Source: American Journal of Hematology
DOI: 10.1002/ajh.23463
Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Yale University, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, University of Southern Maine, International Prevention Research Institute, Gansu University of Traditional Chinese Medicine, United States Department of Health and Human Services
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2014590123