Work

Cerebrodiene: a brain lipid isolated from sleep-deprived cats.

Year: 1994

Type: article

Abstract: We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.91.20.9505

Authors: R A Lerner, G Siuzdak, O Prospero-Garcia, S J Henriksen, D L Boger, B F Cravatt

Institution: Scripps Research Institute

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute on Drug Abuse, National Center for Research Resources

Awards: ION-SPRAY TRIPLE QUADRUPOLE PROTEIN MASS SPECTROMETER, G4799593933, G5312495065